SCHEMBL4807065

SCHEMBL4807065

OC1(C(CN2CCN(Cc3ccccc3)CC2)c2ccc(F)cc2)CCCCC1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 18/20 0.69
KDM4E B2RXH2 1/20 0.60
HTT P42858 1/20 0.60
SLC6A4 P31645 6/20 0.54
SLC6A3 Q01959 6/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4367567 0.83 SLC6A2 (0.71) SLC6A2SLC6A4
Hydrochloric Acid SCHEMBL3954934 0.82 SLC6A2 (0.71) SLC6A2SLC6A4
SCHEMBL5614335 0.80 SLC6A2 (0.76) SLC6A2SLC6A4SLC6A3
SCHEMBL3976036 0.80 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3
SCHEMBL3960458 0.80 SLC6A2 (0.91) SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL3979432 0.79 SLC6A2 (1.00) SLC6A2SLC6A4SLC6A3
SCHEMBL3978146 0.79 SLC6A2 (0.90) SLC6A2SLC6A4SLC6A3
Hydrochloric Acid SCHEMBL3954013 0.79 SLC6A2 (0.93) SLC6A2SLC6A4SLC6A3
SCHEMBL4366903 0.79 SLC6A2 (0.69) SLC6A2SLC6A4SLC6A3
SCHEMBL4885001 0.78 SLC6A2 (0.76) SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846105-A2 USE OF ADRENERGIC ALPHA2B ANTAGONISTS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS Wyeth (US) 2007-10-24 EP claimed
EP-1551413-A1 USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS Wyeth a Corporation of the State of Delaware (US) 2005-07-13 EP claimed
EP-1551380-A1 A METHOD OF TREATING VASOMOTOR SYMPTOMS COMPRISING A COMPOUND HAVING NOREPINEPHRINE REUPTAKE INHIBITOR ACTIVITY AND 5-HT2A ANTAGONISTIC ACTIVITY Wyeth (US) 2005-07-13 EP claimed
US-20050130987-A1 Methods of treating vasomotor symptoms WYETH (US) 2005-06-16 US claimed
WO-2005037260-A2 USE OF ADRENERGIC ALPHAZE ANTAGONISTS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS WYETH (US) 2005-04-28 WO claimed
US-20040152710-A1 Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms WYETH 2004-08-05 US claimed
WO-2004035036-A1 A METHOD OF TREATING VASOMOTOR SYMPTOMS COMPRISING A COMPOUND HAVING NOREPINEPHRINE REUPTAKE INHIBITOR ACTIVITY AND 5-HT2A ANTAGONISTIC ACTIVITY WYETH (US) 2004-04-29 WO claimed
WO-2004035058-A1 USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS WYETH (US) 2004-04-29 WO claimed
EP-0310268-B1 Substituted cycloalkanols AMERICAN HOME PROD (US) 1994-02-02 EP claimed
US-4826844-A ANTIDEPRESSANT, ANXIOLYTIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 1989-05-02 US claimed
EP-0310268-A2 Substituted cycloalkanols AMERICAN HOME PRODUCTS CORPORATION (US) 1989-04-05 EP claimed
US-20080227850-A1 USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS WYETH (US) 2008-09-18 US disclosed
WO-2008060397-A2 METHOD OF TREATING THERMOREGULATORY DISFUNCTION NOVEN THERAPEUTICS, LLC (US) 2008-05-22 WO disclosed
US-7345096-B2 Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms WYETH (US) 2008-03-18 US disclosed
EP-1846105-A2 USE OF ADRENERGIC ALPHA2B ANTAGONISTS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS Wyeth (US) 2007-10-24 EP disclosed
WO-2004035036-A1 A METHOD OF TREATING VASOMOTOR SYMPTOMS COMPRISING A COMPOUND HAVING NOREPINEPHRINE REUPTAKE INHIBITOR ACTIVITY AND 5-HT2A ANTAGONISTIC ACTIVITY WYETH (US) 2004-04-29 WO disclosed
WO-2004035035-A1 USE OF NOREPINEPHRINE REUPTAKE MODULATORS FOR PREVENTING AND TREATING VASOMOTOR SYMPTOMS WYETH (US) 2004-04-29 WO disclosed
EP-0310268-B1 Substituted cycloalkanols AMERICAN HOME PROD (US) 1994-02-02 EP disclosed
US-4826844-A ANTIDEPRESSANT, ANXIOLYTIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 1989-05-02 US disclosed
EP-0310268-A2 Substituted cycloalkanols AMERICAN HOME PRODUCTS CORPORATION (US) 1989-04-05 EP disclosed