Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819386 | 1.00 | POLB (0.50) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL8482453 | 1.00 | POLB (0.50) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL8525578 | 1.00 | POLB (0.50) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL8524021 | 1.00 | POLB (0.50) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL4804132 | 0.94 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL4804141 | 0.94 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL4804145 | 0.94 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL7022852 | 0.89 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL7022855 | 0.89 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AFKBP1A | |
| SCHEMBL1864842 | 0.88 | POLB (0.52) | POLBSMN1; SMN2NPC1RAB9AFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425633-B2 | Pyrrolidine compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2008-09-16 | — | — | US | disclosed |
| US-20070082932-A1 | Pyrrolidine compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2007-04-12 | — | — | US | disclosed |
| US-5942537-A | ADMINISTERING A L-TRANS PYRROLIDINE DERIVATIVE TO INHIBIT THE TRANSPORT OF L-GLUTAMATE OR L-ASPARTATE OR AN EXCITATORY AMINO ACID NEUROTRANSMITTER AWAY FROM A SYNAPSE COMPRISING CONTACTING SYNAPSE WITH PYRROLIDINE DERIVATIVE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0497895-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006536-A1 | METHOD OF INHIBITING THE TRANSPORT OF L-GLUTAMATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082932-A1 | Pyrrolidine compounds | DPP4, DPP7, DPP9 | POLB 1316/4885SMN1; SMN2 4437/4885NPC1 3371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.