Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803006 | 0.76 | MAPK1 (0.45) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL4815057 | 0.70 | BACE1 (0.48) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL479979 | 0.69 | CYP4F2 (0.61) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3550978 | 0.66 | FOLH1 (0.50) | KDM4ERXRAHTTKMT2AHSD17B10 | |
| SCHEMBL19475215 | 0.66 | KMT2A (0.49) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL20676741 | 0.65 | HTT (0.54) | RAB9AALDH1A1NPC1SMN1; SMN2POLB | |
| SCHEMBL14645421 | 0.64 | KMT2A (0.54) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL14646005 | 0.64 | MAPT (0.46) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL10444567 | 0.64 | TSHR (0.62) | ALDH1A1SMN1; SMN2HTTCA1CA2 | |
| SCHEMBL14918369 | 0.64 | CA1 (0.52) | KDM4ERAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459567-B2 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators | WYETH (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2006088694-A1 | SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183792-A1 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators | WYETH (US) | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183792-A1 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators | BACE1, BACE2, PSEN1 | KDM4E 1194/4885RAB9A 666/4885ALDH1A1 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.