Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1728975 | 0.86 | F2R (0.42) | KDM4ENPC1MAPTRAB9AF2R | |
| SCHEMBL14449104 | 0.85 | F2R (0.41) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL5488732 | 0.85 | KDM4E (0.35) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL6544809 | 0.85 | F2R (0.37) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL1731380 | 0.83 | KDM4E (0.34) | KDM4ENPC1MAPTRAB9AF2R | |
| Hydrochloric Acid SCHEMBL1729535 | 0.83 | MAPT (0.38) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL1729646 | 0.81 | F2R (0.48) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL1729603 | 0.81 | F2R (0.40) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL1730337 | 0.81 | F2R (0.40) | KDM4ENPC1MAPTRAB9AF2R | |
| Bromide SCHEMBL1731536 | 0.80 | F2R (0.43) | KDM4ENPC1MAPTRAB9AF2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008128038-A2 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-10-23 | — | — | WO | claimed |