SCHEMBL481144

SCHEMBL481144

N[C@@]1(C(=O)O)CC[C@H](C(=O)O)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 8/20 1.00
GRM2 Q14416 4/20 1.00
GRM3 Q14832 4/20 1.00
CYP1A2 P05177 4/20 1.00
CYP2C19 P33261 4/20 1.00
ALOX15 P16050 3/20 1.00
TDP1 Q9NUW8 2/20 1.00
GRM8 O00222 2/20 1.00
GRM6 O15303 2/20 1.00
LMNA P02545 1/20 1.00
GRM5 P41594 1/20 1.00
MTOR P42345 1/20 1.00
GRM1 Q13255 1/20 1.00
PLCB1 Q9NQ66 1/20 1.00
TSHR P16473 1/20 1.00
ALDH1A1 P00352 2/20 0.68
KDM4E B2RXH2 1/20 0.68
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
CYP2D6 P10635 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4835874 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL3125919 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL935371 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL719389 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL2157698 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL179741 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL235442 1.00 GRM4 (1.00) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL2916853 0.88 GRM4 (0.78) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL4835681 0.88 GRM4 (0.78) GRM4GRM2GRM3CYP1A2CYP2C19
SCHEMBL7271016 0.88 GRM4 (0.78) GRM4GRM2GRM3CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1038023-A1 AGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF THE UAB RESEARCH FOUNDATION (US) 2000-09-27 EP claimed
US-6013672-A ADMINISTERING TO AN INDIVIDUAL SUFFERING FROM HEAD, SPINAL CORD TRAUMA, STROKE AND EPILEPSY A THERAPEUTICALLY EFFECTIVE DOSE OF A METABOTROPIC GLUTAMATE RECEPTOR AGONIST UAB RESEARCH FOUNDATION (US) 2000-01-11 US claimed
US-6001581-A Cation-based bioassay using human metabotropic glutamate receptors SIBIA NEUROSCIENCES, INC. (US) 1999-12-14 US claimed
WO-1999031268-A1 AGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS AND USES THEREOF UAB RESEARCH FOUNDATION (US) 1999-06-24 WO claimed
US-11938106-B2 Treatment of tinnitus using glutamate receptor agonists NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2024-03-26 US disclosed
US-20230038631-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIV (US) 2023-02-09 US disclosed
US-20220142960-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC 2022-05-12 US disclosed
US-20210251928-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIVERSITY 2021-08-19 US disclosed
US-20190160059-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC (US) 2019-05-30 US disclosed
EP-3311842-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS VeroScience LLC (US) 2018-04-25 EP disclosed
WO-2017142543-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2017-08-24 WO disclosed
CN-105579575-A Compositions and methods for treating metabolic disorders VEROSCIENCE LLC 2016-05-11 CN disclosed
EP-0600741-A1 Synthesis of kainic acid ELI LILLY AND COMPANY (US) 1994-06-08 EP disclosed
US-5319095-A Synthesis of kainic acid ELI LILLY AND COMPANY (US) 1994-06-07 US disclosed
EP-0590789-A1 Excitatory amino acid receptor antagonists ELI LILLY AND COMPANY (US) 1994-04-06 EP disclosed
US-5284957-A Substituted 1H- or 2H-tetrazoles ELI LILLY AND COMPANY (US) 1994-02-08 US disclosed
US-5236908-A Using adenosine antagonist GENSIA PHARMACEUTICALS, INC. (US) 1993-08-17 US disclosed
US-5196421-A Treatment of neurological disorders ELI LILLY AND COMPANY (US) 1993-03-23 US disclosed
EP-0518530-A2 Improvements in or relating to excitatory amino acid receptor antagonists ELI LILLY AND COMPANY (US) 1992-12-16 EP disclosed
US-5153196-A Administering for reduction of neurotransmission in nervous system disorders ELI LILLY AND COMPANY (US) 1992-10-06 US disclosed