Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.53 |
| ▸ | CSF1R | P07333 | 7/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.47 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815308 | 0.87 | EGFR (0.53) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4764474 | 0.86 | CHUK (0.47) | EGFRCSF1RCHUKINSRMAPK8 | |
| SCHEMBL4812889 | 0.85 | EGFR (0.53) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4769526 | 0.83 | KDR (0.59) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4766838 | 0.81 | CSF1R (0.60) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4764733 | 0.80 | EGFR (0.59) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4766796 | 0.79 | CSF1R (0.66) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4764349 | 0.79 | EGFR (0.53) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4767041 | 0.78 | EGFR (0.57) | EGFRCSF1RERBB2KDRHDAC3 | |
| SCHEMBL4767084 | 0.78 | EGFR (0.52) | EGFRCSF1RERBB2KDRHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7390805-B2 | 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2008-06-24 | — | — | US | claimed |