Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 12/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12056811 | 0.89 | CCNT1 (0.41) | CDK2CCNCCDK8CSF1RMAPK1 | |
| SCHEMBL906189 | 0.88 | CSF1R (0.43) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12056804 | 0.87 | FYN (0.41) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12056808 | 0.87 | HDAC6 (0.45) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12056813 | 0.86 | CCNT1 (0.42) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12056800 | 0.85 | CSF1R (0.36) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12064800 | 0.84 | CSF1R (0.42) | CDK2CCNCCDK8CSF1RHDAC6 | |
| SCHEMBL906176 | 0.81 | CSF1R (0.46) | CDK2CCNCCDK8CSF1RRET | |
| SCHEMBL5206065 | 0.79 | CSF1R (0.49) | CDK2CCNCCDK8CSF1RCCNT1 | |
| SCHEMBL12056806 | 0.79 | CSF1R (0.42) | CSF1RRETPDGFRBKITSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689715-A4 | TUBULIN INHIBITORS | CYTOPIA RES PTY LTD (AU) | 2008-01-23 | — | — | EP | disclosed |
| EP-1689715-A1 | TUBULIN INHIBITORS | Cytopia Research Pty Ltd (AU) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054199-A1 | TUBULIN INHIBITORS | CYTOPIA RESEARCH PTY LTD (AU) | 2005-06-16 | — | — | WO | disclosed |