Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.69 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.61 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.59 |
| ▸ | FRK | P42685 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818740 | 0.96 | MAPK14 (0.74) | MAPK14HSPB1EPHA3FRK | |
| SCHEMBL4820912 | 0.91 | MAPK14 (0.66) | MAPK14HSPB1EPHA3FRK | |
| SCHEMBL2347126 | 0.86 | CYP17A1 (0.47) | MAPK14 | |
| SCHEMBL5464147 | 0.82 | MAPK14 (0.73) | MAPK14HSPB1EPHA3FRK | |
| SCHEMBL4815165 | 0.82 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL4820829 | 0.82 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL5629868 | 0.81 | MAPK14 (0.88) | MAPK14HSPB1 | |
| SCHEMBL4819879 | 0.81 | MAPK14 (1.00) | MAPK14HSPB1 | |
| SCHEMBL4822293 | 0.81 | CYP17A1 (0.43) | MAPK14 | |
| SCHEMBL4822093 | 0.80 | MAPK14 (0.77) | MAPK14HSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432289-B2 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-10-07 | — | — | US | disclosed |