Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255213 | 0.91 | HDAC1 (0.49) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4819147 | 0.77 | HDAC1 (0.56) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4817432 | 0.77 | HDAC1 (0.59) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4816193 | 0.77 | CNR2 (0.47) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4808840 | 0.77 | TDP1 (0.46) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4819571 | 0.75 | HDAC1 (0.56) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4819566 | 0.75 | HDAC1 (0.56) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL29874896 | 0.74 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL999904 | 0.74 | HDAC1 (1.00) | HDAC1HDAC6HDAC3HDAC2HDAC4 | |
| SCHEMBL4819143 | 0.73 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | claimed |
| EP-1656348-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-05-17 | — | — | EP | claimed |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-16 | — | — | US | claimed |
| WO-2005019174-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | claimed |
| CN-119736336-A | CLEC10A gene modified non-human animal | 百奥赛图(北京)医药科技股份有限公司 | 2025-04-01 | — | — | CN | disclosed |
| CN-118871449-A | Novel carbohydrate derivatives as mimics of blood group A and B antigens | 瑞玛布治疗有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118348134-A | Reagents and methods for screening MPS I, II, IIIA, IIIB, IVA, VI and VII | 华盛顿大学商业中心 | 2024-07-16 | — | — | CN | disclosed |
| CN-112986429-B | Reagents and methods for screening MPS I, II, IIIA, IIIB, IVA, VI and VII | 华盛顿大学商业中心 | 2024-03-29 | — | — | CN | disclosed |
| CN-116926052-A | Use of nucleotides as Am2136 activators | 四川大学华西医院 | 2023-10-24 | — | — | CN | disclosed |
| CN-109053822-B | Glycosyl-containing naphthalimide fluorescent probe and application thereof | 中国农业大学 | 2020-10-09 | — | — | CN | disclosed |
| US-20080139547-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| US-7368572-B2 | Acetylene derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-7332279-B2 | UDP-galactose: β-N-acetyl-glucosamine β1,3 galactosyltransferases, β3gal-T5 | GLYCOZYM APS (DK) | 2008-02-19 | — | — | US | disclosed |
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1656348-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-16 | — | — | US | disclosed |
| WO-2005019174-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139547-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC10, HDAC2 | HDAC1 1/4885HDAC6 10/4885HDAC3 6/4885 |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | HDAC1, HDAC10, HDAC2 | HDAC1 1/4885HDAC6 10/4885HDAC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.