SCHEMBL481524

SCHEMBL481524

NOC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.76
SMN1; SMN2 Q16637 3/20 0.76
ADORA3 P0DMS8 2/20 0.76
ADORA2A P29274 2/20 0.76
ADORA2B P29275 2/20 0.76
DPP4 P27487 1/20 0.76
MEN1 O00255 1/20 0.76
SLC28A1 O00337 1/20 0.76
MAP3K7 O43318 1/20 0.76
SLC28A2 O43868 1/20 0.76
GAPDH P04406 1/20 0.76
MAPK1 P28482 1/20 0.76
STAT6 P42226 1/20 0.76
PI4KA P42356 1/20 0.76
KMT2A Q03164 1/20 0.76
PI4K2B Q8TCG2 1/20 0.76
DOT1L Q8TEK3 1/20 0.76
SLC29A1 Q99808 1/20 0.76
PI4K2A Q9BTU6 1/20 0.76
SLC28A3 Q9HAS3 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17440176 1.00 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL2040670 1.00 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL10997946 0.91 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL12963362 0.91 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL5024895 0.91 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL7803298 0.91 ADORA1 (0.76) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL15788449 0.89 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL15338536 0.89 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL384075 0.89 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL6246363 0.89 ADORA1 (0.74) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 849 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024192269-A2 ENZYMATIC METHODS AND COMPOSITIONS FOR POLYMERIZATION OF PHOSPHORAMIDATE AND THIOPHOSPHORAMIDATE-LINKED DNA THE GENERAL HOSPITAL CORPORATION (US) 2024-09-19 WO claimed
EP-4384614-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES The University of Hong Kong (HK) 2024-06-19 EP claimed
CN-118176298-A Materials and methods for comprehensive definition of adaptive immune responses 香港大学 2024-06-11 CN claimed
CN-117925755-A Synthesis method of nucleoside intermediate 2' -O-methyl guanosine 康羽生命科学技术(苏州)有限公司 2024-04-26 CN claimed
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US claimed
WO-2023016454-A1 MATERIALS AND METHODS TO COMPREHENSIVELY DEFINE ADAPTIVE IMMUNE RESPONSES THE UNIVERSITY OF HONG KONG (CN) 2023-02-16 WO claimed
EP-2316030-B1 PROTEIN SCREEING METHODS WAGNER RICHARD W (US) 2019-08-21 EP claimed
CN-109206464-A A kind of adenosine diphosphate core saccharide compound and preparation method thereof and bioactivity 北京大学 2019-01-15 CN claimed
US-9803193-B2 Protein screening methods X-BODY, INC. (US) 2017-10-31 US claimed
CN-105658242-A MRNA therapy for phenylketonuria 夏尔人类遗传性治疗公司 2016-06-08 CN claimed
US-20070232560-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2007-10-04 US claimed
CN-1320878-C Topical composition for follicular delivery of an ornithine decarboxylase inhibitor WOMEN FIRST HEALTHCARE INC (US) 2007-06-13 CN claimed
EP-1765844-A2 PURINE NUCLEOTIDE DERIVATIVES Lauras AS (NO) 2007-03-28 EP claimed
US-20060240056-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2006-10-26 US claimed
US-20060057583-A1 Novel compositions and methods for controlling the extendability of various components used in copying or amplification steps ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. 2006-03-16 US claimed
WO-2005123755-A2 PURINE NUCLEOTIDE DERIVATIVES LAURAS AS (NO) 2005-12-29 WO claimed
US-6207446-B1 MICROCHIP ARRAY OF IMMOBILIZED SINGLE-STRANDED NUCLEIC ACIDS WHICH ARE HYBRIDIZED TO RNA-PROTEIN FUSIONS; FUSIONS ARE RNA COVALENTLY BONDED TO 3' END OF PROTEIN THROUGH A PEPTIDE ACCEPTOR; PROTEIN IS ENCODED BY RNA; CYCLES OF SCREENING THE GENERAL HOSPITAL CORPORATION 2001-03-27 US claimed
EP-0543949-B1 ENZYMIC ALTERATION OF HAIR GROWTH HANDELMAN JOSEPH H (US) 1997-10-22 EP claimed
CN-1162316-A Oligonucleotide conjugates, compositions and methods for splitting ribonucleic acids NOVATIS CO (CH) 1997-10-15 CN claimed
CN-1039422-A New S-adenosyl methionine decarboxylase inhibitor MERRELL DOW PHARMA (US) 1990-02-07 CN claimed