Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 9/20 | 0.33 |
| ▸ | EEF2K | O00418 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481625 | 1.00 | MAP3K11 (0.41) | MAP3K11MTORPRKDCCALCRLEEF2K | |
| SCHEMBL481626 | 0.81 | MTOR (0.40) | MAP3K11MTORPRKDCCALCRLEEF2K | |
| SCHEMBL976654 | 0.79 | MAP3K11 (0.53) | MAP3K11MTOREEF2KJAK2JAK1 | |
| SCHEMBL482194 | 0.77 | MAP3K11 (0.49) | MAP3K11MTORPRKDCEEF2KJAK2 | |
| SCHEMBL482193 | 0.77 | MAP3K11 (0.49) | MAP3K11MTORPRKDCEEF2KJAK2 | |
| SCHEMBL481717 | 0.76 | MAP3K11 (0.51) | MAP3K11MTORPRKDCEEF2KJAK2 | |
| SCHEMBL481716 | 0.76 | MAP3K11 (0.51) | MAP3K11MTORPRKDCEEF2KJAK2 | |
| SCHEMBL481861 | 0.74 | MTOR (0.67) | MAP3K11MTOREEF2KJAK2JAK1 | |
| SCHEMBL481860 | 0.74 | MTOR (0.67) | MAP3K11MTOREEF2KJAK2JAK1 | |
| SCHEMBL977455 | 0.73 | MTOR (0.61) | MAP3K11MTORJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457913-B1 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARM LLC (US) | 2017-04-19 | — | — | EP | disclosed |
| EP-2090577-B1 | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2457913-A2 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | Signal Pharmaceuticals LLC (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2090577-A2 | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | Signal Pharmaceuticals LLC (US) | 2009-08-19 | — | — | EP | disclosed |