Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817632 | 1.00 | EPHX2 (0.62) | EPHX2EPHX1ALDH1A1LMNACYP2D6 | |
| SCHEMBL4822591 | 0.86 | KDM4E (0.59) | EPHX2EPHX1CYP2D6TPSAB1KDM4E | |
| SCHEMBL4822603 | 0.86 | KDM4E (0.59) | EPHX2EPHX1CYP2D6TPSAB1KDM4E | |
| SCHEMBL311932 | 0.79 | GAA (0.67) | EPHX2EPHX1ALDH1A1NAMPTTPSAB1 | |
| SCHEMBL5476364 | 0.78 | KDM4E (0.71) | ALDH1A1NAMPTTPSAB1KDM4EGAA | |
| SCHEMBL5210565 | 0.78 | GAA (0.69) | EPHX2EPHX1ALDH1A1CYP2D6NAMPT | |
| SCHEMBL23123265 | 0.78 | EPHX1 (0.56) | EPHX2EPHX1ALDH1A1LMNACYP2D6 | |
| SCHEMBL13211230 | 0.77 | EPHX2 (1.00) | EPHX2EPHX1CYP2D6CYP3A4 | |
| SCHEMBL4817641 | 0.77 | EPHX1 (0.47) | EPHX2EPHX1ALDH1A1CYP2D6NAMPT | |
| SCHEMBL23123358 | 0.77 | CYP3A4 (0.52) | EPHX2EPHX1ALDH1A1LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | claimed |
| US-7402606-B2 | Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-22 | — | — | US | disclosed |
| EP-1494663-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SmithKline Beecham Corporation (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003086385-A1 | DERIVATIVES OF 1-(OXOAMINOACETYL) PENTYLCARBAMATE AS CATHEPSIN K INHIBITORS FOR THE TREATMENT OF BONE LOSS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |