Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gatifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.98 |
| ▸ | HPGD | P15428 | 6/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | CLK2 | P49760 | 1/20 | 0.98 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gatifloxacin SCHEMBL3565683 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL982406 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL29765369 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL1380257 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL3565686 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL4818160 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| Gatifloxacin SCHEMBL1380256 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL1046589 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (R)-Gatifloxacin SCHEMBL5670068 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1HPGDKCNH2HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL30910969 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1HPGDKCNH2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269488-A1 | Novel crystalline forms of gatifloxacin | NIDDAM-HILDESHEIM VALERIE | 2008-10-30 | — | — | US | disclosed |
| US-7411067-B2 | Crystalline forms of gatifloxacin | TEVA PHARMACEUTICAL INDUSTRIES LTD (IL) | 2008-08-12 | — | — | US | disclosed |
| EP-1471911-A1 | NOVEL CRYSTALLINE FORMS OF GATIFLOXACIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-11-03 | — | — | EP | disclosed |
| US-20040038988-A1 | Novel crystalline forms of gatifloxacin | TEVA PHARMACEUTICALS USA, INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2003105851-A1 | NOVEL CRYSTALLINE FORMS OF GATIFLOXACIN | TEVA PHARMACEUTICALS INDUSTRIES LTD. (IL) | 2003-12-24 | — | — | WO | disclosed |