⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816023 | 1.00 | — | — | |
| SCHEMBL4808202 | 0.90 | TRPV1 (0.38) | — | |
| SCHEMBL4817315 | 0.90 | TRPV1 (0.38) | — | |
| SCHEMBL4808189 | 0.90 | TRPV1 (0.38) | — | |
| SCHEMBL4817284 | 0.90 | TRPV1 (0.38) | — | |
| SCHEMBL4814061 | 0.85 | GSK3A (0.36) | — | |
| SCHEMBL4814042 | 0.85 | GSK3A (0.36) | — | |
| SCHEMBL4816923 | 0.85 | GSK3A (0.36) | — | |
| SCHEMBL13897672 | 0.82 | TRPV1 (0.50) | — | |
| SCHEMBL3875629 | 0.82 | TRPV1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335672-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-02-26 | — | — | US | disclosed |
| EP-1789413-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006031852-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2006-03-23 | — | — | WO | disclosed |
| US-20060058308-A1 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. | 2006-03-16 | — | — | US | disclosed |