Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.43 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481428 | 0.82 | MTOR (0.80) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL8516109 | 0.77 | MTOR (0.61) | MTORPIK3CAGSK3AMAP3K11RICTOR | |
| SCHEMBL481918 | 0.76 | MTOR (0.80) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL481629 | 0.73 | MTOR (0.84) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL27791109 | 0.72 | MTOR (0.47) | MTORPIK3CAGSK3AMAP3K11RICTOR | |
| SCHEMBL721256 | 0.72 | MTOR (0.89) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL481878 | 0.70 | MTOR (0.73) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL481395 | 0.70 | MTOR (1.00) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL481778 | 0.69 | MTOR (0.84) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL481779 | 0.69 | MTOR (0.84) | MTORPIK3CAGSK3AMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2457913-B1 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | SIGNAL PHARM LLC (US) | 2017-04-19 | — | — | EP | disclosed |
| EP-2457913-A2 | Heteroaryl compounds, compositions thereof, and methods of treatment therewith | Signal Pharmaceuticals LLC (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |