Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.71 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.52 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814116 | 1.00 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4816960 | 0.88 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14408109 | 0.88 | HDAC1 (0.71) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL8276109 | 0.86 | HDAC1 (0.81) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14408105 | 0.84 | HDAC1 (0.81) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4818569 | 0.83 | HDAC3 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4819218 | 0.83 | HDAC3 (1.00) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL6026901 | 0.83 | HDAC1 (0.65) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4806773 | 0.83 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL4814781 | 0.83 | HDAC1 (0.72) | HDAC1HDAC8HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | claimed |
| US-7381749-B2 | Sulfonamides as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1633354-B1 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | INST FOR PHARM DISCOVERY INC (US) | 2008-01-23 | — | — | EP | disclosed |
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| US-7271195-B2 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2007-09-18 | — | — | US | disclosed |
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1773398-A2 | NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| CN-1798733-A | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS INC (US) | 2006-07-05 | — | — | CN | disclosed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | disclosed |
| EP-1635800-A2 | CARBONYL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | Kalypsys, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1633354-A2 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20060030554-A1 | Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. | 2006-02-09 | — | — | US | disclosed |
| WO-2005120515-A2 | NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050026907-A1 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2005-02-03 | — | — | US | disclosed |
| WO-2004110418-A2 | CARBONYL COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | disclosed |
| WO-2004092146-A2 | N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | PTP4A1, PTPRJ, PPM1B | HDAC1 3047/4885HDAC8 4323/4885HDAC3 2966/4885 |
| US-20050026907-A1 | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease | HDAC6, HDAC5, HDAC1 | HDAC1 3/4885HDAC8 11/4885HDAC3 4/4885 |
| US-20060100251-A1 | Substituted phenylalkanoic acids | PTPRJ, PTP4A1, PTPN1 | HDAC1 3343/4885HDAC8 4251/4885HDAC3 2986/4885 |
| US-20060030554-A1 | Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease | HDAC6, HDAC3, HDAC5 | HDAC1 4/4885HDAC8 8/4885HDAC3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.