SCHEMBL4819558

SCHEMBL4819558

Cc1ccc(S(=O)(=O)N2C=CNC(=O)[C@H]2CC(=O)N2CCC(N(C(=O)c3ccccc3)c3ccccc3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB1 P46663 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4170084 0.83 BDKRB1 (0.63) BDKRB1
SCHEMBL4167180 0.81 BDKRB1 (0.56) BDKRB1
SCHEMBL3534250 0.81 BDKRB1 (0.66) BDKRB1
SCHEMBL4181152 0.81 BDKRB1 (0.68) BDKRB1
SCHEMBL4177184 0.81 BDKRB1 (0.60) BDKRB1
SCHEMBL4813499 0.79 BDKRB1 (0.60) BDKRB1
SCHEMBL3536909 0.79 BDKRB1 (0.68) BDKRB1
SCHEMBL4169701 0.78 BDKRB1 (0.65) BDKRB1
SCHEMBL4164984 0.77 BDKRB1 (0.53) BDKRB1
SCHEMBL4173602 0.77 BDKRB1 (0.73) BDKRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1963285-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS Amgen Inc. (US) 2008-09-03 EP claimed
WO-2007067629-A1 BRADYKININ 1 RECEPTOR ANTAGONISTS AMGEN INC. (US) 2007-06-14 WO claimed