Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4820097 | 0.84 | TP53 (0.70) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4819065 | 0.79 | TP53 (0.70) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4815156 | 0.78 | TP53 (0.68) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4813586 | 0.76 | MAPT (0.79) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4819228 | 0.76 | POLB (0.77) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4819273 | 0.76 | TP53 (1.00) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4817800 | 0.76 | TP53 (0.76) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4818996 | 0.74 | MAOB (0.74) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4820362 | 0.73 | TP53 (0.67) | TP53ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL4821180 | 0.73 | TP53 (0.79) | TP53ALDH1A1KDM4EPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411076-B2 | such as 2-chloro-N-(7-hydroxy-2-oxo-2H-1-benzopyran-3-yl)benzamide, used for intensifying the effects of cancer therapy based on DNA injury; protein kinase inhibitors; side effect reduction | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-20050054717-A1 | Coumarin derivative | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054717-A1 | Coumarin derivative | ERCC2, ERCC4, DDB1 | TP53 81/4885ALDH1A1 302/4885KDM4E 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.