Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 14/20 | 0.80 |
| ▸ | AURKA | O14965 | 7/20 | 0.69 |
| ▸ | PLK4 | O00444 | 7/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.69 |
| ▸ | LYN | P07948 | 7/20 | 0.69 |
| ▸ | MET | P08581 | 7/20 | 0.69 |
| ▸ | BLK | P51451 | 7/20 | 0.69 |
| ▸ | STK3 | Q13188 | 7/20 | 0.69 |
| ▸ | ABL1 | P00519 | 6/20 | 0.69 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.69 |
| ▸ | INSR | P06213 | 6/20 | 0.69 |
| ▸ | FYN | P06241 | 6/20 | 0.69 |
| ▸ | CSF1R | P07333 | 6/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.69 |
| ▸ | SRC | P12931 | 6/20 | 0.69 |
| ▸ | FLT1 | P17948 | 6/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 6/20 | 0.69 |
| ▸ | NEK2 | P51955 | 6/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5475882 | 0.96 | KDR (0.73) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4762920 | 0.93 | KDR (0.69) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4827643 | 0.93 | KDR (0.80) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4761642 | 0.92 | KDR (0.68) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL5472468 | 0.92 | KDR (0.82) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4762975 | 0.92 | KDR (0.74) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL5470179 | 0.92 | KDR (0.82) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4763213 | 0.91 | KDR (0.72) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL4720470 | 0.91 | KDR (0.82) | KDRAURKBAURKAPLK4MAP4K4 | |
| SCHEMBL5480156 | 0.90 | KDR (0.68) | KDRAURKBAURKAPLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968979-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007067781-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070135387-A1 | Inhibitors of protein kinases | ABBOTT LABORATORIES | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135387-A1 | Inhibitors of protein kinases | MAP3K20, PACSIN2, MAP4K2 | KDR 2196/4885AURKB 277/4885AURKA 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.