Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.61 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.61 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.61 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL481326 | 0.89 | MTOR (0.72) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481436 | 0.88 | MTOR (0.67) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481531 | 0.87 | MTOR (0.69) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481645 | 0.87 | MTOR (0.66) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481310 | 0.87 | MTOR (0.68) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481813 | 0.85 | MTOR (0.66) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481500 | 0.84 | MTOR (0.73) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL482147 | 0.81 | MTOR (0.68) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL481511 | 0.81 | MTOR (1.00) | MTORPIK3CARICTORRPTORMAPKAP1 | |
| SCHEMBL4054252 | 0.80 | MTOR (0.82) | MTORPIK3CARICTORRPTORMAPKAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |