Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.45 |
| ▸ | PPARA | Q07869 | 11/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL4824341 | 1.00 | PPARG (0.45) | PPARGPPARATSHRHPGDPPARD | |
| Arginine SCHEMBL4826312 | 0.96 | PPARG (0.44) | PPARGPPARATSHRHPGDPPARD | |
| Arginine SCHEMBL4826319 | 0.96 | PPARG (0.44) | PPARGPPARATSHRHPGDPPARD | |
| SCHEMBL4824348 | 0.91 | PPARG (0.38) | PPARGPPARATSHRHPGDLMNA | |
| Arginine SCHEMBL4822377 | 0.90 | PPARG (0.50) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4867119 | 0.90 | PPARG (0.52) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4867150 | 0.90 | PPARG (0.52) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4822370 | 0.90 | PPARG (0.50) | PPARGPPARAPPARD | |
| Arginine SCHEMBL4824934 | 0.89 | PPARG (0.40) | PPARGPPARATSHRHPGD | |
| Arginine SCHEMBL4824931 | 0.89 | PPARG (0.40) | PPARGPPARATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365064-B2 | Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LIMITED (IN) | 2008-04-29 | — | — | US | disclosed |