Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | SRC | P12931 | 13/20 | 0.58 |
| ▸ | ABL1 | P00519 | 11/20 | 0.58 |
| ▸ | KDR | P35968 | 11/20 | 0.58 |
| ▸ | IGF1R | P08069 | 5/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.58 |
| ▸ | LCK | P06239 | 4/20 | 0.58 |
| ▸ | FYN | P06241 | 3/20 | 0.58 |
| ▸ | LYN | P07948 | 3/20 | 0.58 |
| ▸ | PLK4 | O00444 | 2/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.58 |
| ▸ | PAK4 | O96013 | 2/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | INSR | P06213 | 2/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4822108 | 0.88 | EGFR (0.75) | EGFRSRCABL1KDRIGF1R | |
| SCHEMBL4822096 | 0.88 | EGFR (0.75) | EGFRSRCABL1KDRIGF1R | |
| SCHEMBL6220226 | 0.88 | EGFR (0.75) | EGFRSRCABL1KDRIGF1R | |
| Ammonia Solution, Strong SCHEMBL4826337 | 0.87 | EGFR (0.57) | EGFRSRCABL1KDRIGF1R | |
| Ammonia Solution, Strong SCHEMBL4824502 | 0.85 | SRC (0.55) | EGFRSRCABL1KDRIGF1R | |
| Ammonia Solution, Strong SCHEMBL4820345 | 0.82 | SRC (0.60) | EGFRSRCABL1KDRIGF1R | |
| Ammonia Solution, Strong SCHEMBL4818822 | 0.81 | EGFR (0.58) | EGFRSRCABL1KDRIGF1R | |
| Ammonia Solution, Strong SCHEMBL4819764 | 0.78 | EGFR (0.76) | EGFRSRCABL1KDRIGF1R | |
| SCHEMBL6109689 | 0.78 | EGFR (0.77) | EGFRSRCABL1KDRIGF1R | |
| SCHEMBL6110167 | 0.78 | EGFR (0.74) | EGFRSRCABL1KDRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006083-A1 | Pyrazolopyrimidines as therapeutic agents | DPYD, UGT1A1, ABCB1 | EGFR 1992/4885SRC 2167/4885ABL1 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.