Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224193 | 0.88 | HRH3 (0.61) | HRH3CYP2D6HRH1KCNH2CACNA1B | |
| Hydrochloric Acid SCHEMBL4233278 | 0.87 | HRH3 (0.61) | HRH3CYP2D6HRH1KCNH2CACNA1B | |
| SCHEMBL4233013 | 0.87 | HRH3 (0.59) | HRH3HRH1KCNH2TRAP1CACNA1B | |
| SCHEMBL4229884 | 0.86 | HRH3 (0.63) | HRH3CYP2D6HRH1KCNH2CYP3A4 | |
| SCHEMBL4229736 | 0.86 | HRH3 (0.63) | HRH3CYP2D6HRH1KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4229800 | 0.86 | HRH3 (0.58) | HRH3CYP2D6HRH1KCNH2TRAP1 | |
| Hydrochloric Acid SCHEMBL4233207 | 0.85 | HRH3 (0.65) | HRH3CYP2D6HRH1KCNH2 | |
| Hydrochloric Acid SCHEMBL4239620 | 0.85 | HRH3 (0.65) | HRH3CYP2D6HRH1KCNH2 | |
| SCHEMBL4233372 | 0.83 | HRH3 (0.64) | HRH3CYP2D6HRH1KCNH2KCNA5 | |
| Hydrochloric Acid SCHEMBL4236165 | 0.82 | HRH3 (0.65) | HRH3CYP2D6HRH1KCNH2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446103-B2 | Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases | GLAXO GROUP LIMITED (GB) | 2008-11-04 | — | — | US | claimed |
| EP-1554243-A1 | BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES | GLAXO GROUP LIMITED (GB) | 2005-07-20 | — | — | EP | claimed |
| WO-2004037788-A1 | BICYCLIC BENZAMIDE COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGAND USEFUL IN THE TREATMENT OF NEUROLOGICAL DISEASES | GLAXO GROUP LIMITED (GB) | 2004-05-06 | — | — | WO | claimed |