Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 4/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | LYN | P07948 | 3/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | FRK | P42685 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | BLK | P51451 | 3/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257614 | 0.82 | GSK3A (0.36) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL4831382 | 0.79 | BRAF (0.47) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL4831235 | 0.78 | AXL (0.43) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL4828081 | 0.77 | DYRK1A (0.39) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL4828071 | 0.77 | AXL (0.39) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL8291682 | 0.76 | DCLK1 (0.38) | GSK3AGSK3BAXLROCK1MAP4K4 | |
| SCHEMBL2044384 | 0.76 | BRAF (0.46) | MAP4K4ABL1LCKFYNCSF1R | |
| SCHEMBL24479123 | 0.74 | AXL (0.53) | GSK3AGSK3BAXLDGAT1KDR | |
| SCHEMBL4831413 | 0.74 | MAP2K1 (0.50) | BRAFMAP2K1CDK2 | |
| SCHEMBL13506269 | 0.74 | BRAF (0.46) | MAP4K4ABL1LCKFYNCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| US-7446199-B2 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-04 | — | — | US | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1664043-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-14 | — | — | EP | disclosed |
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2005-06-23 | — | — | US | disclosed |
| WO-2005028475-A2 | COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137201-A1 | Compositions useful as inhibitors of protein kinases | MAP3K20, PACSIN2, MAP3K6 | GSK3A 274/4885GSK3B 334/4885AXL 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.