Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709824 | 0.92 | MAPT (0.35) | MAPTTP53NR1H4KDM4EMEN1 | |
| SCHEMBL2207550 | 0.82 | NR1H4 (0.32) | MAPTTP53NR1H4 | |
| SCHEMBL2207549 | 0.82 | NR1H4 (0.32) | MAPTTP53NR1H4 | |
| SCHEMBL2207545 | 0.82 | NR1H4 (0.32) | MAPTTP53NR1H4 | |
| SCHEMBL2205300 | 0.73 | NR1H4 (0.34) | MAPTTP53NR1H4KDM4EMEN1 | |
| SCHEMBL2205293 | 0.73 | NR1H4 (0.34) | MAPTTP53NR1H4KDM4EMEN1 | |
| SCHEMBL2205352 | 0.66 | PDE4B (0.32) | MAPTTP53 | |
| SCHEMBL2205359 | 0.66 | PDE4B (0.32) | MAPTTP53 | |
| SCHEMBL2207542 | 0.65 | — | — | |
| SCHEMBL2205753 | 0.63 | KCNH2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888574-A2 | NEW ANTIBIOTIC DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126171-A2 | NEW ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-11-30 | — | — | WO | disclosed |