Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.76 |
| ▸ | GSK3A | P49840 | 2/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4409605 | 0.91 | MTOR (0.69) | MTORPIK3CAMAP3K11 | |
| SCHEMBL481693 | 0.87 | MTOR (1.00) | MTORPIK3CAGSK3A | |
| SCHEMBL481490 | 0.84 | MTOR (0.73) | MTORPIK3CAGSK3A | |
| SCHEMBL481800 | 0.82 | MTOR (0.80) | MTORPIK3CAGSK3AMAP3K11 | |
| SCHEMBL2206999 | 0.82 | MTOR (1.00) | MTORPIK3CAGSK3A | |
| SCHEMBL481424 | 0.82 | MTOR (1.00) | MTORPIK3CAGSK3A | |
| SCHEMBL481413 | 0.81 | MTOR (1.00) | MTORPIK3CAGSK3A | |
| SCHEMBL481850 | 0.81 | MTOR (0.77) | MTORPIK3CAGSK3A | |
| SCHEMBL481512 | 0.81 | MTOR (0.80) | MTORPIK3CAGSK3A | |
| SCHEMBL481423 | 0.81 | MTOR (0.80) | MTORPIK3CAGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090577-B1 | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2078016-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARM LLC (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2090577-A2 | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | Signal Pharmaceuticals LLC (US) | 2009-08-19 | — | — | EP | disclosed |