SCHEMBL4828860

SCHEMBL4828860

CCN(C[C@H]1CC[C@H](C(=O)O)CC1)c1cc2c(cc1CN(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ncn(C)n1)CCCC2

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CETP P11597 12/20 0.38
CXCR3 P49682 6/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.32
LTC4S Q16873 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1902194 0.99 CETP (0.38) CETPCXCR3PTGDR2LTC4S
SCHEMBL4826680 0.98 CETP (0.38) CETPCXCR3PTGDR2LTC4S
Hydrochloric Acid SCHEMBL1899530 0.98 CETP (0.38) CETPCXCR3PTGDR2LTC4S
SCHEMBL13118450 0.93 CETP (0.34) CETPCXCR3
SCHEMBL1899845 0.93 CETP (0.34) CETPCXCR3PTGDR2
Bicarbonate SCHEMBL5216957 0.92 CETP (0.35) CETPCXCR3
SCHEMBL1903637 0.92 CETP (0.34) CETPCXCR3PTGDR2
SCHEMBL13118426 0.92 CETP (0.34) CETPCXCR3
SCHEMBL5499629 0.92 CETP (0.34) CETPCXCR3PTGDR2
Bicarbonate SCHEMBL5181521 0.90 CETP (0.35) CETPCXCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332514-B2 Dibenzylamine compound and medicinal use thereof JAPAN TOBACCO INC. (JP) 2008-02-19 US claimed
US-7807701-B2 Dibenzylamine compounds and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2010-10-05 US disclosed
US-7807701-B2 Dibenzylamine compounds and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2010-10-05 US disclosed
US-7332514-B2 Dibenzylamine compound and medicinal use thereof JAPAN TOBACCO INC. (JP) 2008-02-19 US disclosed
US-7332514-B2 Dibenzylamine compound and medicinal use thereof JAPAN TOBACCO INC. (JP) 2008-02-19 US disclosed