Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760163 | 0.87 | MAPK14 (0.44) | MAPK14MAPK11 | |
| SCHEMBL4759702 | 0.86 | MAPK14 (0.43) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4014215 | 0.80 | MAPK14 (0.58) | MAPK14MAPK11 | |
| SCHEMBL4013741 | 0.80 | MAPK14 (0.41) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4839439 | 0.78 | MAPK14 (0.46) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4840646 | 0.77 | MAPK14 (0.41) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4841631 | 0.77 | MAPK14 (0.39) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4017606 | 0.76 | MAPK14 (0.48) | MAPK14TRPA1 | |
| SCHEMBL4013735 | 0.76 | MAPK14 (0.40) | MAPK14MAPK11TRPA1 | |
| SCHEMBL4837999 | 0.76 | MAPK14 (0.43) | MAPK14MAPK11TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919470-A1 | FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007023105-A1 | FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | WO | disclosed |