SCHEMBL4829939

SCHEMBL4829939

Cc1c(C(=O)OCC(Cl)(Cl)Cl)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(OCc2ccccc2)cc1.O=C(Cl)C(=O)Cl

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 8/20 0.50
CNR1 P21554 7/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4612373 0.98 CNR2 (0.52) CNR2CNR1
SCHEMBL4892088 0.91 CNR1 (0.44) CNR2CNR1
SCHEMBL4247698 0.89 CNR1 (0.59) CNR2CNR1
SCHEMBL4612821 0.89 LPAR5 (0.42) CNR2CNR1
SCHEMBL4612523 0.87 CNR1 (0.57) CNR2CNR1
SCHEMBL3816975 0.86 CNR2 (0.58) CNR2CNR1
SCHEMBL4612325 0.85 CNR1 (0.62) CNR2CNR1
SCHEMBL14164187 0.84 CNR2 (0.59) CNR2CNR1
SCHEMBL4611371 0.82 CNR1 (0.51) CNR2CNR1
SCHEMBL4611618 0.80 PDE4B (0.47) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910331-A1 PYRAZOLE DERIVATIVES AS CBl MODULATORS AstraZeneca AB (SE) 2008-04-16 EP disclosed
WO-2007010217-A1 PYRAZOLE DERIVATIVES AS CBl MODULATORS ASTRAZENECA AB (SE) 2007-01-25 WO disclosed