Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 9/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4825673 | 0.90 | RPS6KA3 (0.45) | RPS6KA3RPS6KA2FGFR1MAPKAPK2SLC40A1 | |
| SCHEMBL4823794 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2MEN1KMT2AKDM4ERPS6KA3 | |
| SCHEMBL270972 | 0.81 | POLB (0.40) | KMT2AKDM4ERPS6KA3RPS6KA2POLB | |
| SCHEMBL4830051 | 0.81 | SMN1; SMN2 (0.37) | SMN1; SMN2MEN1KMT2AKDM4ERPS6KA3 | |
| SCHEMBL4829961 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2AKDM4ERPS6KA3 | |
| SCHEMBL4826644 | 0.77 | RPS6KA3 (0.39) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL4828067 | 0.72 | RPS6KA3 (0.45) | RPS6KA3RPS6KA2FGFR1MAPKAPK2SLC40A1 | |
| SCHEMBL4790138 | 0.72 | — | — | |
| SCHEMBL4829832 | 0.71 | RPS6KA2 (0.36) | RPS6KA3RPS6KA2FGFR1MAPKAPK2MAPK8 | |
| SCHEMBL4831483 | 0.71 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2AKDM4ERPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348425-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1776368-A1 | INHIBITORS OF HCV REPLICATION | Bristol-Myers Squibb Company (US) | 2007-04-25 | — | — | EP | disclosed |
| US-7153848-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060166964-A1 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY | 2006-07-27 | — | — | US | disclosed |
| US-20060046983-A1 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-02 | — | — | US | disclosed |
| WO-2006020082-A1 | INHIBITORS OF HCV REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166964-A1 | Inhibitors of HCV replication | EIF2AK2, HCCS, IDO1 | SMN1; SMN2 4394/4885MEN1 4615/4885KMT2A 3626/4885 |
| US-20060046983-A1 | Inhibitors of HCV replication | EIF2AK2, HCCS, IDO1 | SMN1; SMN2 4394/4885MEN1 4615/4885KMT2A 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.