Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4383986 | 0.86 | JAK2 (0.68) | MAPTALDH1A1JAK2JAK1JAK3 | |
| SCHEMBL4791242 | 0.85 | JAK2 (0.52) | JAK2JAK1JAK3SMN1; SMN2TYK2 | |
| SCHEMBL14563263 | 0.79 | MAPT (0.75) | MAPTALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL14563204 | 0.78 | MAPT (0.87) | MAPTALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL4385126 | 0.77 | JAK2 (0.64) | MAPTJAK2JAK1JAK3TYK2 | |
| SCHEMBL4383776 | 0.76 | JAK2 (0.64) | JAK2JAK1JAK3TYK2HDAC1 | |
| SCHEMBL4917572 | 0.76 | JAK2 (0.51) | JAK2JAK1JAK3TYK2HDAC1 | |
| SCHEMBL4381858 | 0.75 | JAK2 (0.70) | JAK2JAK1JAK3TYK2HDAC1 | |
| SCHEMBL4383499 | 0.75 | JAK2 (0.70) | JAK2JAK1JAK3TYK2HDAC1 | |
| SCHEMBL4377974 | 0.74 | JAK2 (0.73) | JAK2JAK1JAK3TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979329-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |