SCHEMBL4832391

SCHEMBL4832391

CC(CO[Si](C)(C)C(C)(C)C)Oc1cc(Oc2ccc(S(C)(=O)=O)cc2)cc(C(=O)Nc2nccs2)c1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.79
KCNH2 Q12809 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2906758 1.00 GCK (0.79) GCKKCNH2
SCHEMBL3606989 0.88 GCK (1.00) GCKKCNH2
SCHEMBL1146883 0.88 GCK (1.00) GCKKCNH2
SCHEMBL2928054 0.87 GCK (1.00) GCKKCNH2
SCHEMBL3605207 0.87 GCK (1.00) GCKKCNH2
SCHEMBL3598785 0.86 GCK (1.00) GCKKCNH2
SCHEMBL3604709 0.85 GCK (1.00) GCKKCNH2
SCHEMBL1427230 0.85 GCK (0.59) GCKKCNH2
SCHEMBL2658597 0.85 GCK (1.00) GCKKCNH2
SCHEMBL2656429 0.85 GCK (0.78) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1992623-A1 Heteroaryl benzamide derivative for use as GLK activator in the treatment of diabetes Astra Zeneca AB (SE) 2008-11-19 EP disclosed