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Sugi Predict / Compounds / SCHEMBL4833729

SCHEMBL4833729

SCHEMBL4833729

CN(C(=O)Nc1cc(C(F)(F)F)ccc1F)c1ccc(N2C=Nc3sccc3C2N)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ KDR P35968 8/20 0.33
▸ LCK P06239 5/20 0.33
▸ CSF1R P07333 3/20 0.33
▸ PLK4 O00444 2/20 0.33
▸ AURKA O14965 2/20 0.33
▸ MAPK13 O15264 2/20 0.33
▸ PDPK1 O15530 2/20 0.33
▸ JAK2 O60674 2/20 0.33
▸ CHEK2 O96017 2/20 0.33
▸ ABL1 P00519 2/20 0.33
▸ NTRK1 P04629 2/20 0.33
▸ INSR P06213 2/20 0.33
▸ FYN P06241 2/20 0.33
▸ LYN P07948 2/20 0.33
▸ MET P08581 2/20 0.33
▸ KIT P10721 2/20 0.33
▸ PIM1 P11309 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4826378 0.85 CA12 (0.49) KDRLCKCSF1RPLK4AURKA
SCHEMBL4826385 0.80 — —
SCHEMBL4833818 0.79 RET (0.41) KDRLCKJAK2RETTEK
SCHEMBL4828962 0.77 CSF1R (0.39) LCKCSF1RAURKB
SCHEMBL4831099 0.76 MAPT (0.47) MEN1KMT2AKDRLCKCSF1R
SCHEMBL4833733 0.73 MEN1 (0.36) MEN1TSHRKMT2AKDRLCK
SCHEMBL4825661 0.73 MAPT (0.48) MEN1KMT2AKDRAURKAKIT
SCHEMBL4836423 0.72 KCNJ5 (0.36) MEN1KMT2ACSF1RABL1NTRK1
SCHEMBL4825803 0.71 CA12 (0.46) KDRLCKCSF1RPLK4AURKA
SCHEMBL4836049 0.71 PSEN1 (0.46) MEN1KMT2ANTRK1ROCK2RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050004142-A1 Chemical compounds SMITHKLINE BEECHAM CORPORATION 2005-01-06 — — US claimed
EP-1425284-A2 FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-06-09 — — EP claimed
WO-2003022852-A2 FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-03-20 — — WO claimed
US-20080287466-A1 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF ADAMS JERRY LEROY 2008-11-20 — — US disclosed
US-7427623-B2 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof SMITHKLINE BEECHAM CORPORATION (US) 2008-09-23 — — US disclosed
US-20050004142-A1 Chemical compounds SMITHKLINE BEECHAM CORPORATION 2005-01-06 — — US disclosed
EP-1425284-A2 FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2004-06-09 — — EP disclosed
WO-2003022852-A2 FURO-AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-03-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050004142-A1 Chemical compounds TIE1, KDR, TEK MEN1 303/4885TSHR 3073/4885KMT2A 324/4885
US-20080287466-A1 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF TIE1, TEK, KDR MEN1 1454/4885TSHR 3243/4885KMT2A 334/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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