SCHEMBL483380

SCHEMBL483380

CCCc1nc2c(N)nc3ccccc3c2n1CCCC(=O)OCC

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.61
TLR8 Q9NR97 3/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4004026 0.96 TLR7 (0.62) TLR7TLR8
SCHEMBL4155419 0.94 TLR7 (0.62) TLR7TLR8
SCHEMBL4144360 0.89 TLR8 (0.65) TLR7TLR8
SCHEMBL5617073 0.89 TLR7 (0.67) TLR7TLR8
SCHEMBL4139104 0.88 TLR7 (0.66) TLR7TLR8
SCHEMBL5616933 0.86 TLR7 (0.69) TLR7TLR8
SCHEMBL4145453 0.86 TLR7 (0.58) TLR7TLR8
SCHEMBL5616944 0.85 TLR7 (0.62) TLR7TLR8
SCHEMBL4148628 0.85 TLR7 (0.65) TLR7TLR8
SCHEMBL5616967 0.85 TLR7 (0.67) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152703-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2025-05-15 US disclosed
US-12201684-B2 Compositions for stimulation of mammalian innate immune resistance to pathogens THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-01-21 US disclosed
US-20240417738-A1 IMMUNOTHERAPIES FOR THE TREATMENT OF CANCER OHIO STATE INNOVATION FOUNDATION 2024-12-19 US disclosed
CN-118475357-A Immunotherapy for the treatment of cancer 俄亥俄州创新基金会 2024-08-09 CN disclosed
US-20240033348-A1 METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION Pulmotect, Inc. 2024-02-01 US disclosed
US-11826422-B2 Methods and compositions for adaptive immune modulation BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-11-28 US disclosed
US-20200345842-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2020-11-05 US disclosed
US-10722573-B2 Compositions for stimulation of mammalian innate immune resistance to pathogens THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-07-28 US disclosed
CN-105126072-B Compositions for stimulating innate immune resistance to pathogens in mammals 德克萨斯大学系统董事会 2020-05-15 CN disclosed
EP-3538218-A2 METHODS AND COMPOSITIONS FOR ADAPTIVE IMMUNE MODULATION The Board of Regents of The University of Texas System (US) 2019-09-18 EP disclosed
US-20140194628-A1 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2014-07-10 US disclosed
US-20120082700-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2012-04-05 US disclosed
EP-2411521-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS The Board of Regents of The University of Texas System (US) 2012-02-01 EP disclosed
WO-2010111485-A1 COMPOSITIONS FOR STIMULATION OF MAMMALIAN INNATE IMMUNE RESISTANCE TO PATHOGENS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2010-09-30 WO disclosed
EP-1687307-A4 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES CO (US) 2009-06-17 EP disclosed
US-20070072893-A1 Substituted imidazo ring systems and methods 3M INNOVATIVE PROPERTIES COMPANY 2007-03-29 US disclosed
US-20070072893-A1 Substituted imidazo ring systems and methods 3M INNOVATIVE PROPERTIES COMPANY 2007-03-29 US disclosed
US-20070072893-A1 Substituted imidazo ring systems and methods 3M INNOVATIVE PROPERTIES COMPANY 2007-03-29 US disclosed
EP-1687307-A2 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS 3M Innovative Properties Company (US) 2006-08-09 EP disclosed
WO-2005051317-A2 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-06-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072893-A1 Substituted imidazo ring systems and methods IL2, IRF3, EIF2AK2 TLR7 162/4885TLR8 131/4885
US-20140194628-A1 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS IL2, IRF3, EIF2AK2 TLR7 155/4885TLR8 137/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.