Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833901 | 0.69 | AURKA (0.49) | AURKASRCGSK3BAURKB | |
| SCHEMBL12430988 | 0.67 | AURKA (0.54) | AURKASRCGSK3BAURKB | |
| SCHEMBL5481449 | 0.67 | AURKA (0.54) | AURKASRCGSK3BAURKB | |
| SCHEMBL12431000 | 0.65 | AURKA (0.42) | LRRK2AURKAKDRSRCGSK3B | |
| SCHEMBL5071901 | 0.63 | AURKA (0.43) | LRRK2AURKASRCGSK3BAURKB | |
| SCHEMBL1054022 | 0.63 | ROCK1 (0.51) | AURKAMAP3K5ROCK1KDRCSF1R | |
| SCHEMBL12430714 | 0.62 | AURKA (0.70) | TGFBR1AURKAPRKD1SRCGSK3B | |
| SCHEMBL6467426 | 0.62 | MAP3K5 (0.54) | AURKASYKMAP3K5ROCK1KDR | |
| SCHEMBL2918561 | 0.62 | SYK (0.51) | LRRK2TGFBR1PRKD1SYKKDR | |
| SCHEMBL5069317 | 0.61 | LRRK2 (0.40) | LRRK2AURKAKDRSRCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427681-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-23 | — | — | US | claimed |
| EP-1345928-B1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-02-14 | — | — | EP | claimed |
| US-20040167141-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2004-08-26 | — | — | US | claimed |
| JP-2004516292-A | — | — | 2004-06-03 | — | — | JP | claimed |
| EP-1345928-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-09-24 | — | — | EP | claimed |
| US-20030022885-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED | 2003-01-30 | — | — | US | claimed |
| WO-2002050066-A2 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-06-27 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167141-A1 | Pyrazole compounds useful as protein kinase inhibitors | AURKC, AURKA, GSK3B | LRRK2 351/4885TGFBR1 2363/4885AURKA 2/4885 |
| US-20030022885-A1 | Pyrazole compounds useful as protein kinase inhibitors | AURKC, AURKA, GSK3B | LRRK2 351/4885TGFBR1 2363/4885AURKA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.