SCHEMBL4834705 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	PLK1	P53350	15/20	0.54

▸	PLK3	Q9H4B4	11/20	0.54

▸	PLK2	Q9NYY3	10/20	0.49

▸	MAPK7	Q13164	2/20	0.46

▸	DYRK1A	Q13627	1/20	0.46

▸	BRD4	O60885	4/20	0.45

▸	TAF1	P21675	2/20	0.45

▸	PIP4K2A	P48426	1/20	0.41

▸	PIP4K2B	P78356	1/20	0.41

▸	PARP1	P09874	1/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4729390	0.89	PLK1 (0.56)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4782067	0.88	PLK1 (0.52)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL14221001	0.87	PLK1 (0.54)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4784197	0.87	PLK1 (0.56)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4887339	0.86	PLK1 (0.62)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4782801	0.85	PLK1 (0.53)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4779668	0.85	PLK1 (0.53)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4729386	0.85	PLK1 (0.53)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4782907	0.85	PLK1 (0.53)	PLK1PLK3PLK2MAPK7DYRK1A
SCHEMBL4783143	0.85	PLK1 (0.70)	PLK1PLK3PLK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008040951-A1	COMPOUNDS	ASTRAZENECA AB (SE)	2008-04-10	—	—	WO	disclosed