Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | GPR27 | Q9NS67 | 7/20 | 0.64 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 7/20 | 0.63 |
| ▸ | MMP9 | P14780 | 5/20 | 0.63 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MMP3 | P08254 | 1/20 | 0.61 |
| ▸ | MMP7 | P09237 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828284 | 1.00 | GAA (0.67) | GAAGPR27AVPR2MMP2MMP9 | |
| SCHEMBL4826473 | 0.89 | GAA (0.65) | GAAGPR27AVPR2MMP2MMP9 | |
| SCHEMBL4826470 | 0.89 | GAA (0.65) | GAAGPR27AVPR2MMP2MMP9 | |
| SCHEMBL4832693 | 0.89 | GAA (0.70) | GAAGPR27AVPR2MAPTMEN1 | |
| SCHEMBL4832700 | 0.89 | GAA (0.70) | GAAGPR27AVPR2MAPTMEN1 | |
| SCHEMBL4867851 | 0.84 | GAA (0.64) | GAAGPR27AVPR2MMP2MMP9 | |
| SCHEMBL4867847 | 0.84 | GAA (0.64) | GAAGPR27AVPR2MMP2MMP9 | |
| SCHEMBL4826202 | 0.82 | GAA (0.64) | GAAGPR27AVPR2MMP2MMP3 | |
| SCHEMBL4828226 | 0.82 | GAA (0.67) | GAAGPR27AVPR2MAPTMEN1 | |
| SCHEMBL4828227 | 0.82 | GAA (0.67) | GAAGPR27AVPR2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-7335686-B2 | Method and composition for treating osteoporosis | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-02-26 | — | — | US | disclosed |