Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.42 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16752602 | 0.91 | SCN9A (0.47) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL484120 | 0.89 | SCN9A (0.42) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL484110 | 0.87 | SCN9A (0.47) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL484061 | 0.84 | SCN9A (0.56) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL284065 | 0.81 | SCN9A (0.44) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL328216 | 0.78 | SCN9A (0.50) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| Hydrochloric Acid SCHEMBL281671 | 0.77 | SCN9A (0.49) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL483976 | 0.77 | SCN9A (0.38) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL2305572 | 0.76 | SCN9A (0.59) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL484121 | 0.74 | SCN9A (0.45) | SCN9ASCN7ASCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | claimed |