Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482955 | 1.00 | KCNH2 (0.52) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL1104549 | 0.93 | KCNH2 (0.52) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL483579 | 0.93 | KCNH2 (0.56) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL2833224 | 0.90 | KCNH2 (0.57) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL483794 | 0.89 | KCNH2 (0.51) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL1104545 | 0.86 | KCNH2 (0.50) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL1104556 | 0.86 | KCNH2 (0.50) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL483695 | 0.86 | KCNH2 (0.51) | KCNH2SCN3APARP15PARP10 | |
| SCHEMBL483667 | 0.85 | KCNH2 (0.54) | KCNH2SCN3APRMT5KMT2ATRPC6 | |
| SCHEMBL2835713 | 0.84 | KCNH2 (0.61) | KCNH2SCN3APRMT5KMT2ATRPC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-B1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LTD (GB) | 2012-02-01 | — | — | EP | disclosed |