Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4840538 | 0.93 | KMT2A (0.38) | MAPK14FKBP1ATSHRBRD4SCN5A | |
| SCHEMBL4839247 | 0.91 | KMT2A (0.41) | MAPK14FKBP1ATSHRBRD4SCN5A | |
| SCHEMBL4844592 | 0.87 | MAPK14 (0.43) | MAPK14 | |
| SCHEMBL14018996 | 0.86 | MAPK14 (0.37) | MAPK14FKBP1ATSHRBRD4SCN5A | |
| SCHEMBL4837025 | 0.86 | MAPK14 (0.37) | MAPK14FKBP1ATSHRBRD4SCN5A | |
| SCHEMBL4832587 | 0.86 | CYP1A2 (0.44) | MAPK14TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL4845132 | 0.86 | MAPK14 (0.41) | MAPK14 | |
| SCHEMBL4841046 | 0.85 | SMN1; SMN2 (0.42) | MAPK14TSHRKMT2AALDH1A1 | |
| SCHEMBL4842342 | 0.84 | MAPK14 (0.38) | MAPK14TSHRBRD4SCN9AALDH1A1 | |
| SCHEMBL14019002 | 0.84 | MAPK14 (0.38) | MAPK14TSHRBRD4SCN9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |