Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849551 | 0.96 | CYSLTR1 (0.44) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL4841879 | 0.96 | CYSLTR1 (0.42) | CYSLTR1GPBAR1CYSLTR2PDE10AALDH1A1 | |
| SCHEMBL6087968 | 0.85 | CYSLTR1 (0.56) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL6089203 | 0.84 | CYSLTR1 (0.50) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL4849387 | 0.82 | CYSLTR1 (0.41) | CYSLTR1GPBAR1CYSLTR2PDE10A | |
| SCHEMBL4850014 | 0.82 | SMN1; SMN2 (0.41) | PDE10AALDH1A1MAPTATMSMN1; SMN2 | |
| SCHEMBL4841922 | 0.82 | CYSLTR1 (0.47) | CYSLTR1GPBAR1CYSLTR2ALDH1A1MAPT | |
| SCHEMBL14045448 | 0.79 | CYSLTR1 (0.43) | CYSLTR1GPBAR1CYSLTR2ALDH1A1MAPT | |
| SCHEMBL4856376 | 0.78 | CYSLTR1 (0.50) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL4889143 | 0.78 | CYSLTR1 (0.47) | CYSLTR1GPBAR1CYSLTR2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |
| EP-1177187-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064888-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |