Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | BCHE | P06276 | 4/20 | 0.61 |
| ▸ | ACHE | P22303 | 4/20 | 0.61 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | JUN | P05412 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854071 | 0.89 | ABCG2 (0.60) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL4845314 | 0.89 | ABCG2 (0.60) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL5915526 | 0.86 | ABCG2 (0.73) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL4855944 | 0.85 | ABCG2 (0.69) | ABCG2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL4852275 | 0.85 | ABCG2 (0.69) | ABCG2KDM4ELMNAMAPTSMN1; SMN2 | |
| SCHEMBL7190768 | 0.84 | ABCG2 (0.82) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL7190767 | 0.84 | ABCG2 (0.82) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL4857305 | 0.84 | ABCG2 (0.59) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL4852947 | 0.84 | ABCG2 (0.59) | ABCG2KDM4ELMNAMAPTATM | |
| SCHEMBL7185011 | 0.84 | ABCG2 (0.97) | ABCG2KDM4ELMNAMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |