Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 10/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.58 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 5/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782149 | 0.91 | PLK1 (0.57) | PLK1PLK3PLK2FGFR4TTK | |
| SCHEMBL4779988 | 0.89 | PLK1 (0.57) | PLK1PLK3PLK2TTKPLK4 | |
| SCHEMBL4783604 | 0.89 | PLK1 (0.68) | PLK1PLK3PLK2TTKDCLK1 | |
| SCHEMBL4783883 | 0.89 | PLK1 (0.59) | PLK1PLK3PLK2PRKDCTTK | |
| SCHEMBL4784197 | 0.88 | PLK1 (0.56) | PLK1PLK3PLK2FGFR4BRD4 | |
| SCHEMBL4850091 | 0.87 | PLK1 (0.56) | PLK1PLK3PLK2FGFR4TTK | |
| SCHEMBL14220999 | 0.87 | PLK1 (0.56) | PLK1PLK3PLK2FGFR4TTK | |
| SCHEMBL4782741 | 0.87 | PLK1 (0.59) | PLK1PLK3PLK2PRKDCTTK | |
| SCHEMBL4781984 | 0.87 | PLK1 (0.56) | PLK1PLK3PLK2FGFR4PRKDC | |
| SCHEMBL14221236 | 0.86 | PLK1 (0.55) | PLK1PLK3PLK2FGFR4PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |