Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4846232 | 0.95 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL9188531 | 0.94 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL4848779 | 0.94 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL4847244 | 0.90 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL7510398 | 0.84 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL2353460 | 0.82 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL5935757 | 0.81 | GPBAR1 (0.67) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL7509236 | 0.80 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL898777 | 0.78 | PDE10A (0.47) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL4268808 | 0.76 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2GPBAR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |
| EP-1177187-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064888-A1 | DI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |