Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 17/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 10/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852821 | 1.00 | HRH1 (1.00) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4852885 | 1.00 | HRH1 (1.00) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4847863 | 0.98 | HRH1 (1.00) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4849115 | 0.98 | HRH1 (1.00) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4843476 | 0.98 | HRH1 (1.00) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4850629 | 0.90 | HRH1 (0.82) | HRH1KCNH2CYP2D6CHRM1CHRM2 | |
| SCHEMBL4852437 | 0.89 | HRH1 (0.80) | HRH1KCNH2CYP2D6CHRM1 | |
| SCHEMBL4845900 | 0.86 | HRH1 (0.76) | HRH1KCNH2CYP2D6CHRM1 | |
| SCHEMBL4849485 | 0.86 | HRH1 (0.76) | HRH1KCNH2CYP2D6CHRM1 | |
| SCHEMBL4847305 | 0.86 | HRH1 (0.74) | HRH1KCNH2CYP2D6CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393865-B2 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-07-01 | — | — | US | claimed |
| WO-2006019497-A2 | SLEEP-INDUCING COMPOUNDS AND METHODS RELATED THERETO | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-02-23 | — | — | WO | claimed |
| US-20060014797-A1 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-01-19 | — | — | US | claimed |
| US-7393865-B2 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-20060014797-A1 | Sleep inducing compounds and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014797-A1 | Sleep inducing compounds and methods relating thereto | CHRM1, CNR1, HRH3 | HRH1 11/4885KCNH2 1979/4885CYP2D6 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.