Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 13/20 | 0.33 |
| ▸ | CTSD | P07339 | 7/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134703 | 0.82 | FFAR1 (0.36) | BACE1CTSDBACE2 | |
| SCHEMBL4517007 | 0.78 | BACE1 (0.60) | BACE1CTSDBACE2 | |
| SCHEMBL4787010 | 0.76 | BACE1 (0.36) | BACE1CTSDBACE2 | |
| SCHEMBL4520929 | 0.73 | BACE1 (0.59) | BACE1CTSDBACE2REN | |
| SCHEMBL5134308 | 0.72 | BACE1 (0.43) | BACE1CTSDBACE2 | |
| SCHEMBL5135553 | 0.71 | BACE1 (0.42) | BACE1CTSDBACE2 | |
| SCHEMBL4884929 | 0.71 | BACE1 (0.60) | BACE1CTSDBACE2REN | |
| Hydrochloric Acid SCHEMBL5137186 | 0.70 | BACE1 (0.38) | BACE1CTSDBACE2 | |
| SCHEMBL4511003 | 0.69 | BACE1 (0.57) | BACE1CTSDBACE2REN | |
| SCHEMBL4525769 | 0.69 | BACE1 (0.35) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |