Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.63 |
| ▸ | PIM1 | P11309 | 5/20 | 0.63 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.63 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.63 |
| ▸ | PRKX | P51817 | 4/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.63 |
| ▸ | GSK3A | P49840 | 4/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.63 |
| ▸ | CDK9 | P50750 | 3/20 | 0.63 |
| ▸ | CDK8 | P49336 | 3/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 3/20 | 0.63 |
| ▸ | CDK2 | P24941 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 3/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.63 |
| ▸ | PBK | Q96KB5 | 3/20 | 0.63 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.63 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.63 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858596 | 0.84 | CHEK1 (0.71) | CHEK1 | |
| SCHEMBL4852172 | 0.82 | CHEK1 (0.80) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4860069 | 0.81 | CHEK1 (1.00) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4855761 | 0.81 | CHEK1 (0.62) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4854902 | 0.80 | CHEK1 (0.75) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4858729 | 0.80 | CHEK1 (0.78) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4855752 | 0.79 | CHEK1 (0.79) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4849727 | 0.79 | CHEK1 (0.73) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4850212 | 0.79 | CHEK1 (0.73) | CHEK1AURKBPIM1CDK5TAOK1 | |
| SCHEMBL4849157 | 0.78 | CHEK1 (0.72) | CHEK1AURKBPIM1CDK5TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | claimed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885AURKB 165/4885PIM1 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.