Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.52 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4852227 | 1.00 | KDM4E (0.56) | KDM4EBCHEACHECXCL12APP | |
| SCHEMBL4846784 | 0.88 | BCHE (0.58) | BCHEACHECXCL12MAOBABCG2 | |
| SCHEMBL4857406 | 0.88 | BCHE (0.58) | BCHEACHECXCL12MAOBABCG2 | |
| SCHEMBL4853318 | 0.81 | MAOB (0.62) | KDM4EBCHEACHEAPPMAOB | |
| SCHEMBL4846138 | 0.81 | KDM4E (0.46) | KDM4EBCHEACHECXCL12NPC1 | |
| SCHEMBL4852869 | 0.81 | KDM4E (0.46) | KDM4EBCHEACHECXCL12NPC1 | |
| SCHEMBL4856209 | 0.81 | MAPT (0.52) | KDM4ECXCL12NPC1GAAMAPT | |
| SCHEMBL4846123 | 0.81 | MAPT (0.52) | KDM4ECXCL12NPC1GAAMAPT | |
| SCHEMBL3686655 | 0.81 | CXCL12 (0.52) | CXCL12NPC1MAPTRAB9AKMT2A | |
| SCHEMBL3690691 | 0.81 | CXCL12 (0.52) | CXCL12NPC1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |