Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.56 |
| ▸ | PRKDC | P78527 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189591 | 0.87 | PIK3CG (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL189466 | 0.87 | PIK3CG (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL4849694 | 0.86 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL251943 | 0.85 | PIK3CG (0.58) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL189367 | 0.83 | PIK3CG (0.65) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL4348160 | 0.83 | PIK3CG (0.54) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL189411 | 0.83 | PIK3CG (0.68) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL4636740 | 0.82 | PIK3CG (0.55) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL4636745 | 0.82 | PIK3CG (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC | |
| SCHEMBL4457141 | 0.82 | PIK3CG (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931645-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Exelixis, Inc. (US) | 2008-06-18 | — | — | EP | claimed |
| WO-2007044729-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | claimed |