Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.75 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.64 |
| ▸ | JAK2 | O60674 | 2/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.64 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PRKX | P51817 | 1/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854907 | 0.89 | CHEK1 (0.72) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4847520 | 0.87 | CHEK1 (0.70) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4864764 | 0.87 | CHEK1 (0.60) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4848513 | 0.85 | CHEK1 (0.78) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4857624 | 0.84 | CHEK1 (0.60) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4856189 | 0.83 | CHEK1 (0.82) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4850618 | 0.83 | CHEK1 (0.67) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4847650 | 0.83 | CHEK1 (0.53) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4857573 | 0.83 | CHEK1 (0.76) | CHEK1PDPK1JAK2MAPK8AURKA | |
| SCHEMBL4857595 | 0.82 | CHEK1 (0.79) | CHEK1PDPK1JAK2MAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | CHEK1 46/4885PDPK1 117/4885JAK2 395/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885PDPK1 118/4885JAK2 335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.